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Fig. 1 | Malaria Journal

Fig. 1

From: Systematic review of the role of angiopoietin-1 and angiopoietin-2 in Plasmodium species infections: biomarkers or therapeutic targets?

Fig. 1

Schematic overview of function and localisation of Ang-1, Ang-2 and the Tie-2 receptor. Ang-2 is pre-stored in the Weibel–Palade bodies in endothelial cells and is released upon endothelial cell activation. Ang-2 replaces Ang-1 by binding the Tie-2 receptor, preventing its activation and thereby blocking the anti-inflammatory, anti-apoptotic and tight-junction supporting effects of Ang-1. Ang-1, angiopoietin-1; Ang-2, angiopoietin-2; ICAM-1, E-selectin, VCAM-1, adhesion molecules; PfEMP-1, P. falciparum erythrocyte membrane protein 1; WPB, Weibel–Palade body

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Malaria Journal

ISSN: 1475-2875

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