Fig. 2
Interactions between different regulatory systems and the effects of therapeutics on the determinants. Coagulation, endothelial cell activation and immune system activation are processes that stimulate each other. FTY730, LX2931 and NO inhibit the immune system activation and endothelial cell activation. Rosiglitazone inhibits immune system activation, endothelial cell activation and upregulates CD36, which results in increased phagocytosis of the infected erythrocytes