Fig. 4

Parasitaemia inhibition and survival of mice treated with a fixed dose of harmine-analogues. Five BALB/c mice per group were infected with P. berghei ANKA. The mice were treated with three daily doses of 100 mg/kg of 17A or 21A starting at day-4 post infection. The positive and negative control mice were given three daily doses of 100 mg/kg chloroquine and 10% DMSO, respectively. a Per cent parasitaemia. The graph is the mean parasitaemia and standard error of the mean (SEM) of five mice in a group, and b Kaplan–Meier survival plot of mice treated with the harmine analogues and controls. Asterisk indicates a statistically significant difference between the drug treated mice and the vehicle control group (DMSO)