Fig. 2From: Cytochrome P450 2D-mediated metabolism is not necessary for tafenoquine and primaquine to eradicate the erythrocytic stages of Plasmodium berghei Statistical comparison regarding differences in gametocytemia between WT and CYP2D KO mice. The data were modeled using linear regression with repeated measures with a spatial power law covariance structure. The model included terms for study day, treatment group, mouse strain, and all interactions between the three terms. All point estimates, intervals, and p values therefore represent the differences within each day between mouse strains after adjusting for repeated measurements on the same mice. 40 mg/kg primaquine (PQ), 25 mg/kg tafenoquine (TQ), or vehicle control (VC) administered day 4 relative to intravenous sporozoite (IV SPZ) challenge (day 0) using C57BL/6 wild-type or C57BL/6 CYP2D knock-out mice. N = 10 animals per cohort. (Refer to Additional file 1: Figure S6 for gametocytemia)Back to article page