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Table 1 In vivo P. berghei intravenous (IV) sporozoite challenge causal prophylactic and erythrocytic models

From: Cytochrome P450 2D-mediated metabolism is not necessary for tafenoquine and primaquine to eradicate the erythrocytic stages of Plasmodium berghei

Model

Causal prophylactic model

Erythrocytic treatment model

Drug administration (day)a

−1, 0, and/or +1

+4

Endpointb

Hepatic and erythrocytic parasites (asexual parasitemia)

Erythrocytic parasites: parasitemia (asexual), gametocytemia (sexual)

Technique

IVIS (liver), flow cytometry (parasitemia)

Flow cytometry (parasitemia) microscopy (gametocytemia)

  1. aDay of drug administration relative to IV sporozoite inoculation (day 0). IVIS In vivo imaging system
  2. bAnimals are monitored for 30 days or recrudescence and subsequent euthanasia due to comorbidities