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Table 2 Drug resistance allele frequencies

From: Characterizing the impact of sustained sulfadoxine/pyrimethamine use upon the Plasmodium falciparum population in Malawi

SNP Malawi Other East Africa DRC West Africa South Asia South East Asia South America
Sample size 220 33 56 430 54 1133 21
dhps
 S436A 0.005 0.061 0.107 0.505 0.509 0.313 0
 A437G 0.998 0.894 0.902 0.735 0.843 0.971 0.286
 K540E 0.995 0.894 0.063 0.014 0.778 0.477 0.190
 A581G 0.027 0.091 0.027 0.002 0.156 0.407 0.238
dhfr
 N51I 0.991 0.909 0.982 0.658 0.471 0.897 0.381
 C59R 0.991 0.939 0.821 0.745 0.972 0.996 0
 S108N 1 1 1 0.781 1 0.998 0.952
 I164L 0 0 0 0 0.167 0.438 0
 Double dhfr mutant a 1 1 1 0.728 0.982 0.995 0.381
 Triple dhfr mutant b 0.977 0.848 0.750 0.563 0.392 0.887 0
 Quadruple dhfr Mutant c 0 0 0 0 0.167 0.438 0
dhfr-dhps
 Quintuple genotype d 0.968 0.788 0.036 0.007 0.278 0.421 0
 Quintuple + dhfr I164L 0 0 0 0 0.130 0.266 0
 Quintuple + dhps A581G 0.027 0.091 0.027 0 0.111 0.198 0
crt
 K76T 0 0.485 0.661 0.416 0.889 0.960 1.000
 Q271E 0 0.485 0.643 0.430 0.907 0.935 0
 N326S 0 0 0 0.002 0.241 0.630 0
 I356T 0 0 0.196 0.140 0.833 0.652 0
kelch13
 K189T 0.091 0.061 0.196 0.502 0.130 0.007 0.714
 K189 N 0.005 0 0 0.026 0 0 0
 Y493H 0 0 0 0 0 0.044 0
 C580Y 0 0 0 0 0 0.224 0
gch1
 Promoter duplication 0.968 0 0.446 0.251 0.037 0.003 0
 Whole gene duplication 0 0 0.020 0.023 0.111 0.076 0
  1. DRC Democratic Republic of Congo
  2. aAny two of N51I, C59R or S108N
  3. bN51I, C59R & S108N
  4. cTriple dhfr mutant haplotype with I164L
  5. d dhfr N51I/C59R/S108N haplotype + dhps A437G/K540E haplotype