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Table 2 Combination of mutations related with the resistance in P. falciparum

From: Profile of molecular mutations in pfdhfr, pfdhps, pfmdr1, and pfcrt genes of Plasmodium falciparum related to resistance to different anti-malarial drugs in the Bata District (Equatorial Guinea)

Combination of codons Combination of amino acids Number of mutations Urban area (n = 102) N (%) Rural area (n = 142) N (%) p value Total (n = 244) N (%) 95% CI
pfdhfr
 51/59/108 IRN 3 63 (62%) 110 (78) 0.007 173 (71) 65.31 to 76.69
 51/59/108/164 IRNL 4 0 2 (1.4) 0.168 2 (0.8) −0.32 to 1.92
pfdhfr + pfdhps
 a51/59/108/437 IRNG 4 58 (57) 74 (52) 0.462 132 (54) 47.75 to 60.25
 51/59/108/540 IRNE 4 5 (5) 24 (17) 0.004 29 (12) 7.92 to 16.08
 51/59/108/581 IRNG 4 11 (11) 6 (4) 0.047 17 (7) 3.8 to 10.2
 51/59/108/164/437 IRNLG 5 0 1 (1) 0.58 1 (0.4) −0.39 to 1.19
 b51/59/108/437/540 IRNGE 5 5 (5) 23 (16) 0.006 28 (11) 7.07 to 14.93
 51/59/108/437/581 IRNGG 5 11 (11) 3 (2) 0.004 14 (6) 3.02 to 8.98
 c51/59/108/437/540/581 IRNGEG 6 2 (2) 4 (3) 0.67 6 (2.4) 0.48 to 4.32
pfmdr1
 86/1246 YY 2 1 (1) 3 (2) 0.492 4 (2) 0.24 to 3.76
pfmdr1 + pfcrt
 86/76 YT 2 20 (20) 34 (24) 0.4208 54 (22) 16.8 to 27.2
  1. It shows the prevalence of the different combinations of mutations in each gene (pfdhfr and pfmdr1), and the combination between different genes of P. falciparum: pfdhfr ± pfdhps
  2. ≤0.05 is taken as significance value
  3. aPartially resistant pfdhfr 51/59/108 + pfdhps 437 (51/59/108/437)
  4. bFully resistant pfdhfr 51/59/108 + pfdhps 437/540 (51/59/108/437/540)
  5. cSuper resistant pfdhfr 51/59/108 + pfdhps 437/540/581 (51/59/108/437/540/437) and the combination in pfmdr1 ± pfcrt