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Table 4 Initial drug combinations and follow-on treatment in patients treated with intravenous quinine or intravenous artesunate for severe malaria

From: Severe malaria in Europe: an 8-year multi-centre observational study

Patients

n

%

Treated with intravenous quinine

93

 

 Initial therapy

  Monotherapy

54

58

  Combination with doxycycline

33

36

  Combination with clindamycin

5

5

  Combination with mefloquine

1

1

 Follow-on treatment

  Oral quinine

29

31

  Oral ACT

19

20

  Oral AP

11

12

  Nonea

34

37

Treated with intravenous artesunate

63

 

 Initial therapy

  Monotherapy

42

67

  Combination with doxycycline

13

20

  Combination with clindamycin

6

10

  Combination with mefloquine

2/

3

 Follow-on treatment

  Oral ACT

38

60

  Oral AP

17

27

  Oral quinine

2

3

  Mefloquine

3

5

  Noneb

3

5

  1. Data are number of patients and %
  2. ACT artemisinin-based combination therapy, AP atovaquone-proguanil
  3. a Quinine, doxycycline or clindamycin were given for at least 7 days, n = 2 patients died before initiation of subsequent therapy
  4. b Artesunate, doxycycline, clindamycin were given for at least 7 days