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Table 4 Initial drug combinations and follow-on treatment in patients treated with intravenous quinine or intravenous artesunate for severe malaria

From: Severe malaria in Europe: an 8-year multi-centre observational study

Patients n %
Treated with intravenous quinine 93  
 Initial therapy
  Monotherapy 54 58
  Combination with doxycycline 33 36
  Combination with clindamycin 5 5
  Combination with mefloquine 1 1
 Follow-on treatment
  Oral quinine 29 31
  Oral ACT 19 20
  Oral AP 11 12
  Nonea 34 37
Treated with intravenous artesunate 63  
 Initial therapy
  Monotherapy 42 67
  Combination with doxycycline 13 20
  Combination with clindamycin 6 10
  Combination with mefloquine 2/ 3
 Follow-on treatment
  Oral ACT 38 60
  Oral AP 17 27
  Oral quinine 2 3
  Mefloquine 3 5
  Noneb 3 5
  1. Data are number of patients and %
  2. ACT artemisinin-based combination therapy, AP atovaquone-proguanil
  3. a Quinine, doxycycline or clindamycin were given for at least 7 days, n = 2 patients died before initiation of subsequent therapy
  4. b Artesunate, doxycycline, clindamycin were given for at least 7 days