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Table 1 Baseline characteristics, LAMP assay and RDT results

From: Detection of Plasmodium knowlesi, Plasmodium falciparum and Plasmodium vivax using loop-mediated isothermal amplification (LAMP) in a co-endemic area in Malaysia

Variable P. knowlesi P. falciparum
No. participants 50 20
Age
 Median 32 36
 (IQR) [range] (19–49) [3–72] (28.5–46.5) [19–73]
Gender
 Number male 38 13
 % 76 65
Parasite count/μL
 Geometric mean 1197 7246
 (IQR) [range] (300–3920) [43–46350] (2299–17232) [360–190912]
Severe
 n (%) 0 (0) 4 (20)
Pan LAMP
 Number positive (%) 50 (100) 20 (100)
 Sensitivity % (95% CI) 100 (92.9–100) 100 (83.2–100)
 Limit of detection (parasites/μL) 2.0 20.0
Pf LAMP
 Number positive (%) 0 (0) 20 (100)
 Sensitivity % (95% CI) 0 (0) 100 (83.2–100)
 Specificity % (95% CI) 0 (0) 100 (94.8–100)
 Limit of detection (parasites/μL) 20.0
RDTs
 OptiMAL-IT® Pan pLDH
  n (%) [95% CI] 5 (10) [3.3–21.8]
 OptiMAL-IT® Pf pLDH
  n (%) [95% CI] 3 (6) [1.3–16.5]
 CareStart® non-Pf pLDH
  n (%) [95% CI] 14 (28) [16.2–42.5]