Variable | P. knowlesi | P. falciparum |
---|---|---|
No. participants | 50 | 20 |
Age | ||
Median | 32 | 36 |
(IQR) [range] | (19–49) [3–72] | (28.5–46.5) [19–73] |
Gender | ||
Number male | 38 | 13 |
% | 76 | 65 |
Parasite count/μL | ||
Geometric mean | 1197 | 7246 |
(IQR) [range] | (300–3920) [43–46350] | (2299–17232) [360–190912] |
Severe | ||
n (%) | 0 (0) | 4 (20) |
Pan LAMP | ||
Number positive (%) | 50 (100) | 20 (100) |
Sensitivity % (95% CI) | 100 (92.9–100) | 100 (83.2–100) |
Limit of detection (parasites/μL) | 2.0 | 20.0 |
Pf LAMP | ||
Number positive (%) | 0 (0) | 20 (100) |
Sensitivity % (95% CI) | 0 (0) | 100 (83.2–100) |
Specificity % (95% CI) | 0 (0) | 100 (94.8–100) |
Limit of detection (parasites/μL) | – | 20.0 |
RDTs | ||
OptiMAL-IT® Pan pLDH | ||
n (%) [95% CI] | 5 (10) [3.3–21.8] | – |
OptiMAL-IT® Pf pLDH | ||
n (%) [95% CI] | 3 (6) [1.3–16.5] | – |
CareStart® non-Pf pLDH | ||
n (%) [95% CI] | 14 (28) [16.2–42.5] | – |