Fig. 6

Plasma mediators network. Correlations among 11 mediators during P. vivax infection were plotted in network graphs. Each circle represents a cytokine or chemokine and the connecting lines represent significant correlations between two mediators. Solid and dotted lines, respectively, represent positive and negative correlations. The line thickness represents the significance degree. a P. vivax group (n = 73). b P. vivax sub-group with low parasitaemia (≤500 parasites/cu mm) (n = 34). c P. vivax sub-group with high parasitaemia (> 500 parasites/cu mm) (n = 34). The correlation analyses were evaluated by Spearman correlation test. A p value <0.05 was considered significant