Efficacy of artemether–lumefantrine, artesunate–amodiaquine, and dihydroartemisinin–piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in Angola, 2015

Table 4 Efficacy of first-line anti-malarials in three therapeutic efficacy monitoring sites in Angola, 2015

	Efficacy (95% confidence intervals)
	Benguela		Zaire		Lunda Sul
	ASAQ^a	AL^a	AL^a	DP^b	DP^b	ASAQ^a
Uncorrected
Per-protocol Day 28	90.4 (81–96)	89.4 (80–95)	75.3 (65–83)	95.6 (88–99)	100 (94–100)	100 (92–100)
Per-protocol Day 42	–	–	–	81.9 (72–89)	100 (94–100)	–
Kaplan–Meier estimate Day 28	90.3 (84–97)	89.6 (83–96)	76.0 (68–85)	95.5 (91–100)	100	100
Kaplan–Meier estimate Day 42	–	–	–	82.5 (75–91)	100	–
PCR-corrected
Per-protocol Day 28	99.9 (95–100)	96.1 (89–99)	86.5 (77–92)	98.8 (94–99)	100 (96–100)	100 (94–100)
Per-protocol Day 42	–	–	–	98.5 (92–99)	100 (96–100)	–
Kaplan–Meier estimate Day 28	99.9 (95–100)	96.3 (91–100)	88.1 (81–95)	98.8 (96–100)	100	100
Kaplan–Meier estimate Day 42	–	–	–	98.8 (96–100)	100	–

Per-protocol efficacy defined as proportion adequate clinical and parasitological response (ACPR), Kaplan–Meier estimate calculated from estimate of survival function
ASAQ artesunate–amodiaquine, AL artemether–lumefantrine, DP dihydroartemisinin–piperaquine
^a28-day follow up
^b42-day follow up

ISSN: 1475-2875