Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda

Table 1 Antibody responses to MSP1-19 and AMA-1

Antigen	Age group (years)	Site	No of participants	Median age (IQR)	Median OD (IQR)	p value
Antigen	Age group (years)	Site	No of participants	Median age (IQR)	Median OD (IQR)	Walukuba vs Kihihi	Walukuba vs Nagongera	Kihihi vs Nagongera
MSP1-19	1–4	Walukuba	12	3 (2–4)	0.71 (0.60–1.10)	0.08	0.041	0.44
		Kihihi	18	3 (1–4)	0.90 (0.70–1.17)
		Nagongera	24	1 (1–3)	1.00 (0.73–1.29)
	5–15	Walukuba	16	12 (6–13)	0.80 (0.65–1.25)	0.5	0.4	0.8
		Kihihi	76	12 (8–13)	0.89 (0.63–1.12)
		Nagongera	74	11 (7–13)	0.87 (0.63–1.17)
	>15	Walukuba	64	28 (20–40)	0.82 (0.61–1.1)	0.029	0.011	0.4
		Kihihi	181	35 (25–48)	0.97 (0.70–1.27)
		Nagongera	116	39 (25–55)	1.00 (0.67–1.30)
Total			581
AMA-1	1–4	Walukuba	18	2 (1–3)	0.86 (0.59–1.10)	0.95	0.18	0.19
		Kihihi	21	3 (2–4)	0.79 (0.65–1.11)
		Nagongera	63	3 (2–4)	0.92 (0.67–1.2)
	5–15	Walukuba	76	9 (6–12)	0.92 (0.67–1.07)	0.005	0.0001	0.6
		Kihihi	125	11 (8–13)	1.1 (0.80–1.15)
		Nagongera	251	9 (7–12)	1.1 (0.85–1.2)
	>15	Walukuba	89	27 (22–32)	0.72 (0.61–0.88)	0.0001	0.0007	0.62
		Kihihi	197	34 (22–47)	0.85 (0.68–1.1)
		Nagongera	189	34 (22–50)	0.87 (0.65–1.1)
Total			1029