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Table 1 In vitro anti-malarial activity

From: Anti-malarial effect of novel chloroquine derivatives as agents for the treatment of malaria

Strain

Compound

(IC50, μM)

Relative IC50

(CC50, μM)

Selective index(SI) (CC50/IC50)

Relative SI

3D7

Chloroquine

0.014 ± 0.002

1.00

121.90 ± 8.51

8707.10

1.00

SKM13

0.17 ± 0.01

12.14

93.11 ± 5.56

547.70

0.06

SKM14

0.23 ± 0.01

16.42

47.06 ± 3.21

204.16

0.02

FCR3

Chloroquine

0.62 ± 0.04

1.00

121.90 ± 8.51

196.60

1.00

SKM13

0.37 ± 0.01

0.60

93.11 ± 5.36

251.70

1.28

SKM14

 0.52 ± 0.02

0.84

47.06 ± 3.21

90.50 

0.46

  1. Effects of chloroquine derivatives on the proliferation of CQ-susceptible and resistant strains of P. falciparum
  2. Chloroquine-susceptible (3D7) and -resistant (FCR3) P. falciparum strains were cultured in the presence of increasing concentrations of CQ or each of the CQ derivatives. The values shown are the mean ± standard deviation (SD) from three independent experiments performed in triplicate