Fig. 1
Schematic structure of SURFIN4.1. Extracellular region is divided into 4 parts; N-terminal (Nter), Cys-rich domain (CRD), and variable regions 1 and 2 (Var1 and Var2). Scale bar indicates 100 amino acids (aa). The length of the cytoplasmic region varies among parasite lines due to the frameshift mutations: 3D7 line SURFIN4.1 has a stop codon (first arrowhead, at nt 2498–2503) just after the transmembrane region (tm), another potential frameshift would generate a stop codon (second arrowhead at nt 3894–3903) before 2nd Trp-rich (WR) domain, FCR3 line has a stop codon (third arrowhead at nt 4529–4536) after 2nd WR domain [4], and IT line sequence has no frameshift mutations and contains three WR domains