Selections, frameshift mutations, and copy number variation detected on the surf 4.1 gene in the western Kenyan Plasmodium falciparum population

Table 3 Existence of frameshift mutations in the surf _4.1 region encoding the cytoplasmic region in the western Kenyan and Thai Plasmodium falciparum isolates

	Frameshift (nucleotide positions^a)			Number (%) of parasite line/clone^b
	2498–2503	3894–3903	4529–4536	Western Kenya		Thai
Pattern 1	Yes	Yes	No	8	(35)	17	(47)
Pattern 2	Yes	No	No	14	(61)	5	(14)
Pattern 3	No	Yes	No	0	(0)	1	(3)
Pattern 4	No	No	No	1	(4)	13	(36)
Total				23	(100)	36	(100)
3D7^c	Yes	Yes	No
FCR3^c	No	No	Yes
IT^d	No	No	No
PrCDC^d	No	No	No

^a Nucleotide positions are after 3D7 line sequence
^b Pattern 1 contains KK14-92-B7, KN14-098-D1, KT14-111-H2, KU14-044-D2, KU14-050-B3, KU14-071-D4, KU14-226-G5, KU14-257-A7, MS804, MS807-H3, MS836, MS808, MS812, MS828, MS827, MS838, MS830, MS814-F1, MS814-H1, MS815-A2, MS818-C2, MS833-B4, MS840, MS841, and MS829-B5; pattern 2 contains KK14-02-B9, KK14-53-F6, KN14-076-B6, KT14-158-G3, KU14-042-D12, KU14-061-B1, KU14-062-A8, KU14-110-C4, KU14-119-D4, KU14-127-B12, KU14-170-A10, KU14-175-D6, KU14-211-D1, KU14-217-B5, MS811, MS813, MS835A1, MS844-A4, and MS947; pattern 3 contains MS843; and pattern 4 contains KU14-086-B3, MS805, MS806, MS809, MS810, MS816, MS817, MS819-A3, MS822-G8, MS825, MS837, MS842, MS946, and MS948
^c GenBank accession numbers for 3D7 and FCR3 lines are AL844503 and AB759920, respectively
^d PFIT_0400900 and PRCDC_0005300 from GeneDB, Wellcome Trust Sanger Institute, UK (both are 2015-06-18 version)

ISSN: 1475-2875