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Table 1 Pfnhe-1 ms4760 types

From: Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976–78

ms4760 haplotype Chlorproguanil Pyrimethamine Chloroquine Vitamin B Total
Number of previously described ms4760 haplotypes with no variation in block Ia 22 25 25 17 89
Number of novel ms4760 haplotypes with no variation in block Ib 4 2 13 d 6 25
Number of novel ms4760 haplotypes with variation in block Ic 9 17 0 e 16 42
Total no. of different haplotypes 13 29 10 23 55
Total no. of samples 35 44 38 39 156
  1. Resistance associated alleles are shown in italics
  2. aPreviously described ms4760-1, -3, -4, -5, -7, -28, -98 and Mali_15 with no variation in block I
  3. bms4760 haplotypes Lib_01 to Lib_15 with no variation in block I
  4. cms4760 haplotypes Lib_19 to Lib_47 with variation in block I
  5. dThe frequency of samples with no variation in block I was higher in the CQ treated village compared with the frequencies in the villages treated with CPGN (P = 0.028), PYR (P = 0.001), placebo (P = 0.068) and with pooled data from all villages (P = 0.001)
  6. eThe frequency of samples with variation in block I was lower in the CQ treated village when compared with separate and pooled frequencies from the other villages (P < 0.001)