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Table 3 Allele frequencies at resistance associated pfdhps codons 436, 437, 514, 540, 581 and 613

From: Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976–78

Village

S436

A437

I514

K540

A581

A613

613 S

Chlorproguanil

40/40

40/40

32/32

32/32

32/32

29/32 (91%)

3 (9%)

Pyrimethamine

38/38

38/38

38/38

38/38

38/38

38/38

0 a

Chloroquine

30/30

30/30

26/26

26/26

26/26

19/26 (73%)

7(27%)

Vitamin B

40/40

40/40

40/40

40/40

40/40

35/39 (90%)

4 (10%)

  1. Resistance associated alleles are shown in italics
  2. aThe frequency of samples with the resistance associated pfdhps 613S was lower in the pyrimethamine treated village compared to pooled frequencies from the other villages (P < 0.01) and the village using CQ (P = 0.001)
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Malaria Journal

ISSN: 1475-2875

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