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Table 4 Diagnostic values of case management algorithm, by age group, transmission season, and malaria transmission risk zone

From: Assessment of the utility of a symptom-based algorithm for identifying febrile patients for malaria diagnostic testing in Senegal

Risk zone

Age group (years)

Season

TP

FP

FN

TN

SENS

% (95% CI)

SPEC

% (95% CI)

NPV

% (95% CI)

PPV

% (95% CI)

North (low)

<5

Dry

1

135

0

160

100.0 (2.5–100.0)

54.2 (48.4–60.0)

100.0 (a)

0.7 (0.7–0.8)

Rainy

4

165

1

207

80.0 (28.4–99.5)

55.6 (50.4–60.8)

99.5 (97.3–99.9)

2.4 (1.5–3.7)

All year

5

300

1

367

83.3 (36.9–99.6)

55.0 (51.2–58.8)

99.7 (98.4–100.00)

1.6 (1.1–2.4)

≥5

Dry

2

192

0

129

100.0 (15.8–100.0)

40.2 (34.8–45.8)

100.0 (a)

1.0 (0.9–1.1)

Rainy

11

265

0

161

100.0 (71.5–100.0)

37.8 (33.2–42.6)

100.0 (a)

4.0 (3.7–4.3)

All year

13

457

0

290

100.0 (75.3–100.0)

38.8 (35.3–42.4)

100.0 (a)

2.8 (2.6–2.9)

Centre (mod)

<5

Dry

14

156

5

193

73.7 (48.8–90.9)

55.3 (49.9–60.6)

97.5 (94.5–98.8)

8.2 (6.3–10.7)

Rainy

66

123

21

187

75.9 (65.5–84.4)

60.3 (54.6–65.8)

89.9 (85.9–92.9)

34.9 (30.9–39.2)

All year

80

279

26

380

75.5 (66.2–83.3)

57.7 (53.8–61.5)

93.6 (91.2–95.4)

22.3 (20.0–24.8)

≥5

Dry

22

262

4

88

84.6 (65.1–95.6)

25.1 (20.7–30.0)

95.7 (89.8–98.2)

7.7 (6.6–9.1)

Rainy

132

170

23

72

85.2 (78.6–90.4)

29.8 (24.1–35.9)

75.8 (67.2–82.7)

43.7 (41.1–46.3)

All year

154

432

27

160

85.1 (79.0–89.9)

27.0 (23.5–30.8)

85.6 (80.3–89.6)

26.3 (24.8–27.8)

South (high)

<5

Dry

28

100

27

137

50.9 (37.1–74.7)

57.8 (51.2–64.2)

83.5 (79.2–87.2)

21.9 (17.2–27.4)

Rainy

183

53

88

72

67.5 (61.6–73.1)

57.6 (48.4–66.4)

45.0 (39.4–50.7)

77.5 (73.5–81.2)

All year

211

153

115

209

64.7 (59.3–70.0)

57.7 (52.5–62.9)

64.5 (60.5–68.3)

58.0 (54.4–61.4)

≥5

Dry

80

132

35

87

69.6 (60.3–77.8)

39.7 (33.2–46.5)

71.3 (64.3–77.4)

37.7 (34.0–41.6)

Rainy

339

49

63

20

84.3 (80.4–87.7)

29.0 (18.7–41.2)

24.1 (17.1–32.9)

87.4 (85.5–89.0)

All year

419

181

98

107

81.0 (77.4–84.3)

37.2 (31.6–43.0)

52.2 (46.4–58.0)

69.8 (67.7–71.9)

Dakar (mixed)

<5

Dry

7

85

1

180

87.5 (47.4–99.7)

67.9 (61.9–73.5)

99.4 (96.6–99.9)

7.6 (5.7–10.1)

Rainy

9

117

7

273

56.3 (29.9–80.3)

70.0 (65.2–80.3)

97.5 (95.7–98.6)

7.1 (4.6–10.8)

All year

16

202

8

453

66.7 (44.7–84.4)

69.2 (65.5–72.7)

98.3 (97.0–99.0)

7.3 (5.5–9.7)

≥5

Dry

15

220

2

162

88.2 (63.6–98.5)

42.4 (37.4–47.5)

98.8 (95.6–99.7)

6.4 (5.3–7.6)

Rainy

162

184

21

127

88.5 (83.0–92.8)

40.8 (35.3–46.5)

85.8 (79.8–90.2)

46.8 (44.2–49.5)

All year

177

404

23

289

88.5 (83.3–92.6)

41.7 (38.0–45.4)

92.6 (89.4–94.9)

30.5 (28.8–32.2)

  1. TP, true positive: algorithm recommends testing, and RDT is positive; FP, false positive: algorithm recommends testing, and RDT is negative; FN, false negative: algorithm does not recommend testing, and RDT and positive; TN, true negative: algorithm does not recommend testing, and RDT is negative
  2. SENS sensitivity, SPEC specificity, NPV negative predictive value, PPV positive predictive value
  3. aUnable to calculate