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Table 4 Diagnostic values of case management algorithm, by age group, transmission season, and malaria transmission risk zone

From: Assessment of the utility of a symptom-based algorithm for identifying febrile patients for malaria diagnostic testing in Senegal

Risk zone Age group (years) Season TP FP FN TN SENS
% (95% CI)
SPEC
% (95% CI)
NPV
% (95% CI)
PPV
% (95% CI)
North (low) <5 Dry 1 135 0 160 100.0 (2.5–100.0) 54.2 (48.4–60.0) 100.0 (a) 0.7 (0.7–0.8)
Rainy 4 165 1 207 80.0 (28.4–99.5) 55.6 (50.4–60.8) 99.5 (97.3–99.9) 2.4 (1.5–3.7)
All year 5 300 1 367 83.3 (36.9–99.6) 55.0 (51.2–58.8) 99.7 (98.4–100.00) 1.6 (1.1–2.4)
≥5 Dry 2 192 0 129 100.0 (15.8–100.0) 40.2 (34.8–45.8) 100.0 (a) 1.0 (0.9–1.1)
Rainy 11 265 0 161 100.0 (71.5–100.0) 37.8 (33.2–42.6) 100.0 (a) 4.0 (3.7–4.3)
All year 13 457 0 290 100.0 (75.3–100.0) 38.8 (35.3–42.4) 100.0 (a) 2.8 (2.6–2.9)
Centre (mod) <5 Dry 14 156 5 193 73.7 (48.8–90.9) 55.3 (49.9–60.6) 97.5 (94.5–98.8) 8.2 (6.3–10.7)
Rainy 66 123 21 187 75.9 (65.5–84.4) 60.3 (54.6–65.8) 89.9 (85.9–92.9) 34.9 (30.9–39.2)
All year 80 279 26 380 75.5 (66.2–83.3) 57.7 (53.8–61.5) 93.6 (91.2–95.4) 22.3 (20.0–24.8)
≥5 Dry 22 262 4 88 84.6 (65.1–95.6) 25.1 (20.7–30.0) 95.7 (89.8–98.2) 7.7 (6.6–9.1)
Rainy 132 170 23 72 85.2 (78.6–90.4) 29.8 (24.1–35.9) 75.8 (67.2–82.7) 43.7 (41.1–46.3)
All year 154 432 27 160 85.1 (79.0–89.9) 27.0 (23.5–30.8) 85.6 (80.3–89.6) 26.3 (24.8–27.8)
South (high) <5 Dry 28 100 27 137 50.9 (37.1–74.7) 57.8 (51.2–64.2) 83.5 (79.2–87.2) 21.9 (17.2–27.4)
Rainy 183 53 88 72 67.5 (61.6–73.1) 57.6 (48.4–66.4) 45.0 (39.4–50.7) 77.5 (73.5–81.2)
All year 211 153 115 209 64.7 (59.3–70.0) 57.7 (52.5–62.9) 64.5 (60.5–68.3) 58.0 (54.4–61.4)
≥5 Dry 80 132 35 87 69.6 (60.3–77.8) 39.7 (33.2–46.5) 71.3 (64.3–77.4) 37.7 (34.0–41.6)
Rainy 339 49 63 20 84.3 (80.4–87.7) 29.0 (18.7–41.2) 24.1 (17.1–32.9) 87.4 (85.5–89.0)
All year 419 181 98 107 81.0 (77.4–84.3) 37.2 (31.6–43.0) 52.2 (46.4–58.0) 69.8 (67.7–71.9)
Dakar (mixed) <5 Dry 7 85 1 180 87.5 (47.4–99.7) 67.9 (61.9–73.5) 99.4 (96.6–99.9) 7.6 (5.7–10.1)
Rainy 9 117 7 273 56.3 (29.9–80.3) 70.0 (65.2–80.3) 97.5 (95.7–98.6) 7.1 (4.6–10.8)
All year 16 202 8 453 66.7 (44.7–84.4) 69.2 (65.5–72.7) 98.3 (97.0–99.0) 7.3 (5.5–9.7)
≥5 Dry 15 220 2 162 88.2 (63.6–98.5) 42.4 (37.4–47.5) 98.8 (95.6–99.7) 6.4 (5.3–7.6)
Rainy 162 184 21 127 88.5 (83.0–92.8) 40.8 (35.3–46.5) 85.8 (79.8–90.2) 46.8 (44.2–49.5)
All year 177 404 23 289 88.5 (83.3–92.6) 41.7 (38.0–45.4) 92.6 (89.4–94.9) 30.5 (28.8–32.2)
  1. TP, true positive: algorithm recommends testing, and RDT is positive; FP, false positive: algorithm recommends testing, and RDT is negative; FN, false negative: algorithm does not recommend testing, and RDT and positive; TN, true negative: algorithm does not recommend testing, and RDT is negative
  2. SENS sensitivity, SPEC specificity, NPV negative predictive value, PPV positive predictive value
  3. aUnable to calculate