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Table 7 Relapse characteristics

From: A systematic review of the clinical presentation, treatment and relapse characteristics of human Plasmodium ovale malaria

Authors Diagnostic method primary infection Treatment primary infection Dosage primary infection PQ therapy primary infection? Time between primary infection and 1st relapse (weeks) Diagnostic method 1st relapse Treatment 1st relapse PQ therapy 1st relapse? Time between 1st and 2nd relapse (weeks) Diagnostic method 2nd relapse Treatment 2nd relapse PQ therapy 2nd relapse? Time between 2nd and 3rd relapse (weeks) Treatment 3rd relapse
Bottieau [28] MIC Quinine 1.5 g/day for 5 days Y, “standard regimen” (presumably 15 mg/day for 14 days) 7 MIC Chloroquine 1.5 g over 3 days Y, 7 mg/kg over 3 weeks NA NA NA NA NA NA
Doxycycline 100 mg/day for 7 days
Quinine–doxycycline Y, “standard regimen” 2 Chloroquine, dosage unknown Y, 10 mg/kg over 4 weeks NA NA NA NA NA NA
Chloroquine N 60 Atovaquone–proguanil, dosage unknown Y, 5 mg/kg over 6 weeks 78 MIC Atovaquone–proguanil, then chloroquine Y, 8 mg/kg over 3 weeks NA NA
Collins et al. [29] MIC Chloroquine 1.5 g over 3 days N 22 MIC Chloroquine, dosage unknown N 17 MIC Chloroquine, dosage unknown NA NA
MIC Chloroquine 1.5 g over 3 days N 10 MIC NA NA NA NA NA NA
MIC Chloroquine 1.5 g over 3 days N 15 MIC NA NA NA NA NA NA
MIC Chloroquine 1.5 g over 3 days N 24 MIC NA NA NA NA NA NA
MIC Chloroquine 1.5 g over 3 days N 20 MIC NA NA NA NA NA NA
Nathwani et al. [30] MIC Chloroquine 15 mg/day for 14 days Y, 15 mg/day for 14 days 17 MIC Chloroquine 1.5 g over 3 days Y, 30 mg/day for 21 days NA NA NA NA NA NA
Chin et al. [31] MIC Quinine sulphate 650 mg 8-hourly for 5 days N MIC Quinine sulphate 650 mg 8-hourly for 5 days N 5 MIC Quinine sulphate 650 mg 8-hourly for 5 days N Quinine sulphate 650 mg 8-hourly for 5 days
MIC Quinine sulphate 650 mg 8-hourly for 5 days N 2 MIC Quinine sulphate 650 mg 8-hourly for 5 days N 20 MIC Quinine sulphate 650 mg 8-hourly for 5 days N NA NA
MIC Quinine sulphate 650 mg 8-hourly for 5 days N 36 MIC Quinine sulphate 650 mg 8-hourly for 5 days N NA NA NA NA NA NA
MIC Quinine sulphate 650 mg 8-hourly for 5 days N MIC Quinine sulphate 650 mg 8-hourly for 5 days N MIC Quinine sulphate 650 mg 8-hourly for 5 days N NA NA
MIC Chloroquine 600 mg single dose N MIC Chloroquine 600 mg single dose N MIC Chloroquine 600 mg single dose Y, 15 mg/day for 14 days NA NA
Garnham et al. [32] MIC Chloroquine N 15 MIC No treatment N 10 MIC No treatment N NA NA
MIC Chloroquine N 14 MIC No treatment N 14 MIC No treatment N NA NA
Jeffery [33] MIC Chloroquine N 21 MIC Chloroquine, dosage unknown N 22a MIC NA NA
MIC chloroquine N 34 MIC chloroquine, dosage unknown Y, dosage unknown NAa NA NA NA NA NA
  1. MIC microscopy, Y yes, N no, NA not applicable, – not mentioned in the original publication
  2. aThe patient who did not receive primaquine treatment for his 1st relapse developed a second one, however it was not clear from the article, which one of the two patients developed the described second relapse