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Fig. 5 | Malaria Journal

Fig. 5

From: Rhesus macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional outcomes

Fig. 5

Region- and epitope-specific responses. a, b Points represent optical density from a peptide ELISA at 1:100 serum dilution. Peptides comprised of the N-terminus (NT), conserved region I plus NVDPNANP repeats region (RI + repeat), and the cysteine rich region II of C-terminus (RII). c, d Points represent per cent inhibition of HRP-labelled 5D5 (N-terminus), 2A10 (NANP repeat) or 2F12 (C-terminus) mAb in the presence of individual sera. Inhibition is expressed as the percent decrease in optical density obtained by ELISA with mAb alone. Bars represent group means and whiskers represent standard error of the mean (SEM) for mouse (n = 5) and rhesus (n = 7) serum from 2 weeks post-third vaccination. P values are shown for statistically significant differences between CSP and Qβ-CSP determined by two-tailed t tests

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