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Table 1 Relative enhancement of CSP titres by conjugation to Qβ

From: Rhesus macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional outcomes

  Mouse Rhesus
(Qβ-CSP: CSP titre ratio) (Qβ-CSP: CSP titre ratio)
FL NANP C-term FL NANP C-term
Post 1 3.3** 930**** 8.8** 4.1 12* 5.1*
Post 2 2.4** 10*** 1.8 1.2 2.4 2.2*
Post 3 2.5* 2.9* 2.5 1.3 2.4 1.4
  1. CSP titre ratios of group geometric mean antibody titre for mice (n = 7) and rhesus (n = 5) 2–3 weeks after each immunization. ELISA was run against FL, NANP, and C-terminus plate antigens. Significant differences between log-transformed CSP and Qβ-CSP titres at each time point for each plate antigen was determined by two-tailed t test, denoted by * (P < 0.05), ** (P < 0.01), *** (P < 0.001) or **** (P < 0.0001)