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Table 3 G6PD haplotypes and associated phenotypes identified in western Madagascar study sites

From: Prevalence and genetic variants of G6PD deficiency among two Malagasy populations living in Plasmodium vivax-endemic areas

Study site

G6PD FST phenotype

Phenotype frequency

B a

A b

A- c

Mediterranean d

Ampasimpotsy

Normal

89

88

1

0

0

Intermediate

7

4

2

1

0

Deficient

11

1

0

10

0

Mandoto/Miandrivazo

Normal

165

159

6

0

0

Intermediate

9

6

0

3

0

Deficient

10

0

0

9

1

  1. Includes samples that were tested by both diagnostic approaches (n = 291)
  2. a B wild-type cDNA sequence, GenBank X03674. 84 B haplotypes carry SNP 1311C > T; 437Y > Y
  3. b A 126N > D associated with nonsynonymous SNP 376A > G. One A haplotype carries SNP 1311C > T; 437Y > Y
  4. c A- 68V > M and 376 N > D associated with nonsynonymous snps 202G > A and 376A > G, respectively. Five A- haplotypes, all from Ampasimpotsy, are 68V > M associated with nonsynonymous snp 202G > A
  5. d Mediterranean 188S > F and 437Y > Y associated with nucleotide snps 563C > T and 1311C > T, respectively
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Malaria Journal

ISSN: 1475-2875

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