Table 2 Adverse events reported by treatment
Total (n = 470) | Artemether + lumefantrine (n = 204) | Artesunate + mefloquine (n = 119) | Dihydroartemisinin + piperaquine (n = 147) | |
|---|---|---|---|---|
n (%) | n (%) | n (%) | n (%) | |
Number of adverse events per patient | ||||
0 | 345 (73) | 150 (74) | 80 (67) | 115 (78) |
1 | 60 (13) | 25 (12) | 16 (13) | 19 (13) |
2 | 64 (14) | 29 (14) | 22 (19) | 13 (9) |
3 | 1 (<1) | 0 | 1 (<1) | 0 |
Most frequent type of adverse event reported | ||||
Dizziness | 30 (6.4) | 19 (9.3) | 9 (7.6) | 2 (1.4) |
Nausea | 29 (6.2) | 13 (6.4) | 8 (6.7) | 8 (5.4) |
Vomiting | 27 (5.7) | 8 (3.9) | 9 (7.6) | 10 (6.8) |
Loss of appetite | 19 (4.0) | 9 (4.4) | 3 (2.5) | 7 (4.8) |
Insomnia | 15 (3.2) | 2 (1.0) | 13 (10.9) | 0 |
Palpitation | 14 (3.0) | 11 (5.4) | 2 (1.7) | 1 (0.7) |
Diarrhoea | 13 (2.8) | 3 (1.5) | 3 (2.5) | 7 (4.8) |
Abdominal pain | 10 (2.1) | 3 (1.5) | 7 (5.9) | 0 |
Asthaenia | 10 (2.1) | 1 (0.5) | 4 (3.4) | 5 (3.4) |
Headache | 6 (1.3) | 6 (2.9) | 0 | 0 |
Cough | 6 (1.3) | 2 (1.0) | 0 | 4 (2.7) |
Joint/muscle pain | 5 (1.1) | 3 (1.5) | 1 (0.8) | 1 (0.7) |
Skin rash | 3 (0.6) | 2 (1.0) | 1 (0.8) | 0 |
Nightmare | 2 (0.4) | 0 | 2 (1.7) | 0 |