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Table 4 Clinical characteristics of falciparum malaria patients

From: Genotypic and phenotypic characterization of G6PD deficiency in Bengali adults with severe and uncomplicated malaria

  Case 1 Case 2 Case 3 G6PD normal  
SM (n = 77) n UM (n = 61) n
G6PD variant Orissa Orissab Kerala-Kalyanb    
Florescent spot test 0 h Deficient ND Intermediate 64 N/10 I/1 D 75 47 N/13 I 60  
Demographics
 Age (years) 27 32 55 28 (22–40) 77 28 (21–35) 61 0.8468
 Sex (%, M) M F F 49 (64%) 77 42 (69%) 61  
 Previous malaria Y N N 16 (21%) 76 21 (34%) 61 0.191
 Days of fever 10 13 30 7 (6–10) 77 7 (4–10) 61 0.0656
 Blackwater fever N N N 16 (21%) 77 2 (3%) 61 <0.0001
 Severity of disease UM SM UM  
Physical examination
 Temperature (°C) 40.0 36.8 37.0 38.2 (37.5–39.2) 77 38.2 (37.2–39.4) 61 0.89
 Glasgow coma score 15 15 15 9 (8–14) 77 15 (15–15) 61  
 Respiratory rate (per min) 40 32 28 36 (28–44) 77 26 (22–32) 61 <0.00001
 Splenomegaly N N N 16 (21%) 77 7 (11%) 61 N = 37/33
Laboratory parameters
 Parasite count per μla 171,821 10,425 2520 100,229 (15,826–353,690) 77 22,244 (1200–102,615) 61 0.0006
 PfHRP2 (mg/ml) 384 1297 172 3036 (1497–9946) 71 563 (143–1300) 57 <0.0001
 CFH (μM) 1.4 1.6 0.9 5.3 (2.5–12.7) 75 2.0 (1.3–3.6) 57 <0.0001
 Haemoglobin (g/dl) 10.9 5.3 7.8 8.9 (7.0–10.9) 77 11.6 (8.9–13.2) 61 <0.0001
 LDH (U/l) 141 967 275 643 (526–912) 77 322 (230–383) 28 <0.0001
 Total bilirubin (mg/dl)a 1.4 1.4 0.6 2.0 (1.0–3.3) 77 1.0 (0.7–1.6) 60 0.0001
 Creatinine (mg/dl) 1.1 4.5 1.1 1.4 (1.1–2.9) 77 1.2 (1.0–1.4) 60 0.0002
 Urine pH 5.06 5.00 6.45 5.57 (5.28–5.83) 57 6.00 (5.62–6.43) 36 0.0004
 pH 7.47 7.37 7.39 7.38 (7.32–7.43) 77 7.44 (7.40–7.47) 61 <0.0001
 Bicarbonate (mmol/l) 19.8 13.9 22.6 17.3 (14.6–19.5) 77 21.4 (19.6–23.5) 61 <0.0001
 pCO2 (mmHg) 28 24 37 29 (25–33) 77 32 (28–35) 61 0.0024
 Lactate (mmol/l) 2.11 0.71 1.94 3.9 (2.3–6.1) 77 1.6 (1.2–2.1) 61 <0.0001
  1. G6PD normal patients were either normal on FST or had normal G6PD sequence results
  2. Data are number (%) or median (IQR), unless otherwise indicated
  3. M male, F female, Y yes, N no, UM uncomplicated malaria, SM severe malaria
  4. aGeometric mean (95% CI)
  5. bHeterozygous