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Table 3 Prevalence of Pfdhps and Pfdhfr mutations in isolates collected in three health facilities in Hodh Elgharbi region, Mauritania in 2010

From: Characterization of Plasmodium falciparum genes associated with drug resistance in Hodh Elgharbi, a malaria hotspot near Malian–Mauritanian border

Gene

Codon

Aa

n (%)

Aioun

Kobeni

Tintane

Total

Pfdhps

S436A/F

S

17 (32)

33 (26)

32 (38)

82 (31)

S/A

10 (19)

16 (13)

10 (12)

36 (14)

A

26 (49)

75 (60)

43 (51)

144 (55)

F

0

2 (2)

0

2 (1)

A437G

A

33 (62)

96 (76)

43 (51)

172 (65)

A/G

10 (19)

12 (10)

9 (11)

31 (12)

G

10 (19)

18 (14)

32 (38)

60 (23)

K540E/A

K

52 (98)

122 (97)

85 (100)

259 (98)

K/A

0

1 (0.8)

0

1 (0.4)

K/E

0

2 (2)

0

2 (1)

E

1 (2)

1 (1)

0

2 (1)

Pfdhfr

N51I

N

31 (58)

73 (55)

39 (47)

143 (53)

N/I

10 (19)

16 (12)

11 (13)

37 (14)

I

12 (23)

44 (33)

33 (40)

89 (33)

C59R

C

32 (60)

68 (51)

40 (48)

140 (52)

C/R

9 (17)

18 (14)

9 (11)

36 (13)

R

12 (23)

47 (35)

34 (41)

93 (35)

S108N/T

S

31 (58)

68 (52)

42 (51)

141 (53)

S/T

1 (2)

3 (2)

1 (1)

5 (2)

S/N

7 (13)

14 (11)

6 (7)

27 (10)

T/N

2 (4)

1 (1)

6 (7)

9 (3)

T

2 (4)

0

1 (1)

3 (1)

N

10 (19)

46 (35)

27 (33)

83 (31)

I164L

I

52 (98)

131 (99)

73 (88)

256 (96)

I/L

1 (2)

1 (1)

10 (12)

12 (4)

  1. aa amino acid, n number of isolates. All isolates had the wild-type Pfdhps alleles in codons 581 and 613. Mutant alleles are denoted in bold characters