Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity

Malaria Journal

Table 2 Summary of multiple linear regression analysis for predictors of cytokine levels

	TNF-α		IL-12		IFN-γ		IL-1β		IL-2		IL-6		IL-8		IL-4		IL-10		IL-13		IL-7		GM-CSF
Variables (df, error)	F	P	F	P	F	P	F	P	F	P	F	P	F	P	F	P	F	P	F	P	F	P	F	P
Age (1,171)	0.48	0.490	2.02	0.15	0.37	0.54	1.41	0.23	1.74	0.18	1.41	0.236	0.76	0.38	2.00	0.159	0.00	0.954	2.98	0.086	0.23	0.635	2.35	0.127
Parasitemia (1,171)	0.80	0.37	0.44	0.510	0.25	0.61	0.02	0.88	1.47	0.22	0.02	0.880	0.29	0.590	0.29	0.59	8.99	0.003 ^#*	1.79	0.183	0.24	0.625	1.27	0.261
Sex (1,171)	0.82	0.366	0.39	0.53	0.01	0.914	0.10	0.750	3.18	0.076	0.10	0.750	0.01	0.937	0.08	0.782	0.04	0.837	0.18	0.67	0.12	0.729	6.64	0.011^#
Transmission Intensity (2,171)	2.43	0.091	6.51	0.002^#*	6.38	0.001^#*	7.36	0.001^#*	9.26	<0.0001^#*	7.36	0.001^#*	9.78	<0.0001^#*	8.09	<0.0001^#*	13.26	<0.0001^#*	5.04	0.007^#	10.02	<0.0001^#*	1.74	0.178

Table summarizing the multiple linear regression analyses. Cytokine levels were the outcome variables, while age, parasitemia, sex and transmission intensity (sites) were the predictor variables. Transmission intensity was the major significant predictor of cytokine levels
F = F-statistic
df = Degree of freedom
Error = Residual degrees of freedom
^#Statistically significant predictor
*Significant after Bonferroni’s P value adjustment

ISSN: 1475-2875