Fig. 4

AUC of different dosing schemes and their potential relationship with efficacy. a The area of both columns is the same (A = B), hence, in the presence of constant biting rate, the total number of mosquitoes killed by A and B might me similar, even if B does not reach the same Cmax. b If the theoretical LC₁₀₀ is surpassed (light blue area), the drug consumed to reach such plasma levels is partly wasted because it does not contribute to efficacy and may in turn increase the possibility of side effects. Columns are used only for illustration. LC ₁₀₀ lethal concentration 100