From: Ivermectin to reduce malaria transmission II. Considerations regarding clinical development pathway
 | Residual transmission | Insecticide resistance | Transmission | Targeted for elimination | Artemisinin resistance | Burden of malaria | Testable |
---|---|---|---|---|---|---|---|
Elimination in the GMS | +++ | + | + | +++ | +++ | + | Possibly |
Elimination in selected areas of sub-Saharan Africa | ++ | +++ | +++ | +++ | – | +++ | Yes |
Reduce disease burden in high-transmission areas | + | Any | +++ | + | Â | +++ | Yes |
Stem insecticide resistance in well-defined areas | Any | ++++ | Any | + | Any | + | Difficult |
Elimination from hotspots in the endgame | ++ | +++ | +++ | +++ | Any | +++ (local) | Doubtful |
Stem of outbreaks | + | Any | ++ | Any | Any | + | Doubtful |