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Table 2 Kinome scan profile of NCGC00100599

From: Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening

Kinase

% Control

Kinase

% Control

ABL1(Q252H)-phosphorylated

9.9

RSK2(Kin.Dom.2-C-terminal)

29

PIK3CD

10

IKK-epsilon

31

CDK4-cyclinD3

15

JAK2(JH1domain-catalytic)

31

ERBB3

17

MYLK

31

TYK2(JH1domain-catalytic)

19

PRKG2

32

TRKA

22

KIT(A829P)

34

SNRK

27

MAP3K3

34

ALK(C1156Y)

28

MST4

34

  1. NCGC00100599 was profiled at 10 μM against a diverse panel of 468 kinases by DiscoverX