Assessment of copy number variation in genes related to drug resistance in Plasmodium vivax and Plasmodium falciparum isolates from the Brazilian Amazon and a systematic review of the literature

Table 1 Description of samples included in this study by period of collection, gender, age and parasitemia

Region (N)^b	Period	Gender (male, %)	Median age, years (IQR^c)	Parasitemia, geometric mean (range)^d
Patients infected by P. falciparum ^a
Amapá (10)	2004–2005	60	35 (27–46)	1306 (605–2500)
Rondônia (4)	2008	75	42 (32–52)	5004 (1520–24,650)
Mato Grosso (18)	2002–2012	83	36 (26–43)	1505 (62–56,660)
Patients infected by P. vivax ^a
Mato Grosso (13)	2005–2012	92	35 (17–49)	4816 (992–17,500)
Rondônia (22)	2008	73	41 (23–50)	1840 (95–10,770)

^a First line treatment for uncomplicated P. falciparum malaria during sample collection: QN + doxycycline + PQ (2001–2007) and ACT (after 2007). Treatment scheme for P. vivax therapy: CQ + PQ [6]
^b State of sample collection and number of isolates analysed
^c Interquartile range
^d Parasites/µL

ISSN: 1475-2875