Table 2 Comparison of sensitivity and specificity of Plasmodium detection methods
From: Comparison of methods for detecting asymptomatic malaria infections in the China–Myanmar border area
Reference | Pos | Neg | Pos | Neg | Pos | Neg | Total |
|---|---|---|---|---|---|---|---|
CLIP-PCR | nD-PCR | nRT-PCR | |||||
LM | |||||||
Pos | 6 | 6 | 11 | 1 | 12 | 0 | 12 |
Neg | 13 | 980 | 13 | 980 | 175 | 818 | 993 |
Total | 19 | 986 | 24 | 981 | 187 | 818 | 1005 |
Sensitivity (95% CI) | 50.0% (46.9–53.0%) | 91.7% (90–93.4%) | 100% (100–100%) | ||||
Specificity (95% CI) | 98.7% (92.3–100%) | 98.7% (92.3–100%) | 82.4% (60.8–100%) | ||||
Reference | LM | nD-PCR | nRT-PCR | Total | |||
|---|---|---|---|---|---|---|---|
CLIP-PCR | |||||||
Pos | 6 | 13 | 12 | 7 | 19 | 0 | 19 |
Neg | 6 | 980 | 12 | 974 | 168 | 818 | 986 |
Total | 12 | 993 | 24 | 981 | 187 | 818 | 1005 |
Sensitivity (95% CI) | 31.6% (28.7–34.5%) | 63.2% (60.1–66.2%) | 100% (100–100%) | ||||
Specificity (95% CI) | 99.4% (95.9–100%) | 98.8% (93.9–100%) | 83.0% (66.0–99.9%) | ||||
Reference | CLIP-PCR | LM | nRT-PCR | Total | |||
|---|---|---|---|---|---|---|---|
nD-PCR | |||||||
Pos | 12 | 12 | 11 | 13 | 24 | 0 | 24 |
Neg | 7 | 974 | 1 | 980 | 163 | 818 | 981 |
Total | 19 | 986 | 12 | 993 | 187 | 818 | 1005 |
Sensitivity (95% CI) | 50.0% (46.9–53.1%) | 45.8% (42.7–49.0%) | 100% (100–100%) | ||||
Specificity (95% CI) | 99.3% (95.9–100%) | 99.9% (98.6–100%) | 83.38% (68.5–98.3%) | ||||
Reference | CLIP-PCR | nD-PCR | LM | Total | |||
|---|---|---|---|---|---|---|---|
nRT-PCR | |||||||
Pos | 19 | 168 | 24 | 163 | 12 | 175 | 187 |
Neg | 0 | 818 | 0 | 818 | 0 | 818 | 818 |
Total | 19 | 986 | 24 | 981 | 12 | 993 | 1005 |
Sensitivity (95% CI) | 10.2% (8.1–12.2%) | 12.8% (10.5–15.1%) | 6.4% (4.8–8.1%) | ||||
Specificity (95% CI) | 100% (100–100%) | 100% (100–100%) | 100% (100–100%) | ||||