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Table 2 Comparison of sensitivity and specificity of Plasmodium detection methods

From: Comparison of methods for detecting asymptomatic malaria infections in the China–Myanmar border area

Reference Pos Neg Pos Neg Pos Neg Total
CLIP-PCR nD-PCR nRT-PCR
LM
 Pos 6 6 11 1 12 0 12
 Neg 13 980 13 980 175 818 993
 Total 19 986 24 981 187 818 1005
Sensitivity (95% CI) 50.0% (46.9–53.0%) 91.7% (90–93.4%) 100% (100–100%)  
Specificity (95% CI) 98.7% (92.3–100%) 98.7% (92.3–100%) 82.4% (60.8–100%)
Reference LM nD-PCR nRT-PCR Total
CLIP-PCR
 Pos 6 13 12 7 19 0 19
 Neg 6 980 12 974 168 818 986
 Total 12 993 24 981 187 818 1005
Sensitivity (95% CI) 31.6% (28.7–34.5%) 63.2% (60.1–66.2%) 100% (100–100%)  
Specificity (95% CI) 99.4% (95.9–100%) 98.8% (93.9–100%) 83.0% (66.0–99.9%)  
Reference CLIP-PCR LM nRT-PCR Total
nD-PCR
 Pos 12 12 11 13 24 0 24
 Neg 7 974 1 980 163 818 981
 Total 19 986 12 993 187 818 1005
Sensitivity (95% CI) 50.0% (46.9–53.1%) 45.8% (42.7–49.0%) 100% (100–100%)  
Specificity (95% CI) 99.3% (95.9–100%) 99.9% (98.6–100%) 83.38% (68.5–98.3%)  
Reference CLIP-PCR nD-PCR LM Total
nRT-PCR
 Pos 19 168 24 163 12 175 187
 Neg 0 818 0 818 0 818 818
 Total 19 986 24 981 12 993 1005
Sensitivity (95% CI) 10.2% (8.1–12.2%) 12.8% (10.5–15.1%) 6.4% (4.8–8.1%)  
Specificity (95% CI) 100% (100–100%) 100% (100–100%) 100% (100–100%)