Fig. 2

The ICAM-1 receptor, but not the CD36 receptor, plays a role in sequestration. a A higher proportion of schizonts (Sz) were seen in peripheral blood of icam-1−/− mice at the time of schizogony (GMT 13:30, day 7 post-infection, **p < 0.01) compared to wild-type mice. Proportions of rings (R) and trophozoites (T) were similar to control wt mice. The proportion of peripheral blood schizonts seen in peripheral blood of cd36−/− mice was similar to that of control wt mice (n = 6). b Tissue parasites were reduced in spleen and liver of icam-1−/− mice, after the infection peak (day 9, *p < 0.05). At earlier time points (day 5 or 7 post-infection) no significant differences in tissue parasites were seen. Infections of cd36−/− mice showed similar sequestration patterns to those observed in wild type animals throughout the infection (n = 5)