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Fig. 6 | Malaria Journal

Fig. 6

From: Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 8 in patients with P. vivax infection

Fig. 6

Cytokine response to the rPvMSP8 antigen. PBMCs from individuals that exhibited recovery from P. vivax infection for 8–10 weeks (n = 15) were stimulated with rPvMSP8. PHA and medium culture were the positive and negative control in each experiment, respectively. a The levels of the IFN-γ and IL-10 cytokines were detected in 96-h culture supernatants by ELISA. The data show the average value of cytokine levels. b IFN-γ-producing cells and IL-10-producing cells respond to PvMSP8 antigen were identified via intracellular staining after 6 h of in vitro stimulation and analysed using flow cytometry. PMA/ionomycin and medium culture were the positive and negative control in each experiment, respectively. Significance was determined using the Wilcoxon signed-rank test, with the level of significance set at P < 0.05

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Malaria Journal

ISSN: 1475-2875

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