Fig. 2

The transient nature of the protection provided by RTS,S/AS01 and the associated changes in anti-CSP antibody concentration following primary vaccination and administration of a booster dose modelled on the basis of the results of phase 2 and phase 3 RTS,S/AS01 efficacy trials. d Shows anti-CSP antibody titres and f shows the percentage efficacy after primary and booster immunization. Red lines indicate infants vaccinated at the age of 6–12 weeks, blue lines those vaccinated at the age of 5–17 months. Dotted lines indicate children who recived a booster dose and solid lines those who did not (From White et al. [14])