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Fig. 3 | Malaria Journal

Fig. 3

From: Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia

Fig. 3

KH001_053 exhibits resistance to piperaquine (PPQ). a EC50 growth curves for eight parasite isolates in different PPQ concentrations. Percent growth is displayed on the y-axis and the PPQ concentration (nM) is represented in a log scale on the x-axis, with KH001_053 indicated by red triangles. b Relative growth is shown (percent growth) for TRAC isolates exposed to 125 nM PPQ for 72 h starting with 0–6 h old rings, with individual parasite lines represented on the x-axis. Colours correspond to parasites with RSA0–3h ≤0.2% that lack pfkelch13 mutations (sensitive, green); RSA0–3h >3% that lack pfkelch13 mutations (discordant, blue); and, RSA0–3h >1% that harbour with pfkelch13 mutations (resistant, red). Data were analysed by Kruskal–Wallis test followed by Dunn’s multi-comparison test. p values: *<0.1, **<0.01, ****<0.0001

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