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Table 3 Risk factors associated with recrudescence and new infection after anti-malarial treatment in pregnant women in Nchelenge, Zambia (2010–2014)

From: Artemisinin-based combination therapy in pregnant women in Zambia: efficacy, safety and risk of recurrent malaria

  Hazard ratio 95% CI p value
Risk factors associated with recrudescence
Treatment
 AL 10.47 2.18–50.19  
 MQAS 1.56 0.26–9.38
 DHAPQ 1 1 (reference) <0.01a
Maternal age (15–19 years) 5.07 1.01–25.43 0.05
Gestational age
 2nd Trimester 2.35 0.76–7.40  
 3rd Trimester 1 1 (reference) 0.14
Gravidity
 Primigravidae 1.44 0.51–4.38  
 Multigravidae 1 1 (reference) 0.47
Parasite density (>2000/µL) 3.35 1.03–10.10 0.04
Study treatment dosage (mg/kg for 3 days) 2.10 0.75–5.89 0.16
Risk factors associated with malaria new infection
Treatment
 AL 4.71 3.10–7.15  
 MQAS 1.59 1.02–2.46
 DHAPQ 1 1 (reference) <0.01a
Maternal age (15–19 years) 1.78 1.26–2.52 <0.01a
Parasite density (>2000/µL) 1.46 1.09–1.94 0.01
Anaemia (Hb <11.0 g/dL) 1.56 1.05–2.32 0.03
Gravidity
 Primigravidae 1.11 0.80–1.54  
 Multigravidae 1 1 (reference) 0.52
Study treatment dosage (mg/kg for 3 days) 1.00 0.74–1.37 0.98
  1. ap value of the joint effect of treatment