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Table 3 Risk factors associated with recrudescence and new infection after anti-malarial treatment in pregnant women in Nchelenge, Zambia (2010–2014)

From: Artemisinin-based combination therapy in pregnant women in Zambia: efficacy, safety and risk of recurrent malaria

 

Hazard ratio

95% CI

p value

Risk factors associated with recrudescence

Treatment

 AL

10.47

2.18–50.19

 

 MQAS

1.56

0.26–9.38

 DHAPQ

1

1 (reference)

<0.01a

Maternal age (15–19 years)

5.07

1.01–25.43

0.05

Gestational age

 2nd Trimester

2.35

0.76–7.40

 

 3rd Trimester

1

1 (reference)

0.14

Gravidity

 Primigravidae

1.44

0.51–4.38

 

 Multigravidae

1

1 (reference)

0.47

Parasite density (>2000/µL)

3.35

1.03–10.10

0.04

Study treatment dosage (mg/kg for 3 days)

2.10

0.75–5.89

0.16

Risk factors associated with malaria new infection

Treatment

 AL

4.71

3.10–7.15

 

 MQAS

1.59

1.02–2.46

 DHAPQ

1

1 (reference)

<0.01a

Maternal age (15–19 years)

1.78

1.26–2.52

<0.01a

Parasite density (>2000/µL)

1.46

1.09–1.94

0.01

Anaemia (Hb <11.0 g/dL)

1.56

1.05–2.32

0.03

Gravidity

 Primigravidae

1.11

0.80–1.54

 

 Multigravidae

1

1 (reference)

0.52

Study treatment dosage (mg/kg for 3 days)

1.00

0.74–1.37

0.98

  1. ap value of the joint effect of treatment