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Table 3 Effect of crude hydromethanolic root extract of Indigofera spicata on level of parasitemia and survival time of mice infected with P. berghei in curative test

From: Antiplasmodial activity of Indigofera spicata root extract against Plasmodium berghei infection in mice

Group

Level of parasitemia

Survival date

D3

D4

D5

D6

D7

% change

NS

18.4 ± 1.78

24.8 ± 1.8

30.4 ± 0.68

40.75 ± 1.65

51 ± 2.00

6.2 ± 0.37

200 mg/kg IS

17.6 ± 1.72

22 ± 1.67

22.6 ± 1.89a,2

20.6 ± 1.5a,3

21.7 ± 1.76a,3

58.18

6.8 ± 0.84

400 mg/kg IS

16.2 ± 1.66

18.8.4 ± 1.16

16.2 ± 0.74a,3,b,1

15.8 ± 1.36a,3,b,2

13.3 ± 1.59a,3,b,3

74.12

7.8 ± 0.37a,1

600 mg/kg IS

18.8 ± 1.16

18.2 ± 1.56a,1

15.4 ± 2.09a,3,b,2

10.4 ± 1.21a,3,b,3

10.2 ± 0.58a,3,b,3

80.00

8.2 ± 0.84a,2

25 mg/kg CQ

16.6 ± 1.96

11.4 ± 1.21a,3,b,2,c,1,d,1

4 ± 0.45a,3,b,3,c,3,d,3

0.4 ± 0.25a,3,b,3,c,3,d,3

0.00a,3,b,3,c,3,d,3

100

>15a,3,b,3,c,3,d,3

  1. Data are expressed as mean ± SEM; n = 5
  2. IS, Indigofera spictata; CQ, chloroquine
  3. aCompared to control
  4. bTo 200 mg/kg
  5. cTo 400 mg/kg
  6. dTo 600 mg/kg
  7. 1p < 0.05
  8. 2p < 0.01
  9. 3p < 0.001