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Fig. 1 | Malaria Journal

Fig. 1

From: The blood schizonticidal activity of tafenoquine makes an essential contribution to its prophylactic efficacy in nonimmune subjects at the intended dose (200 mg)

Fig. 1

Plasma-concentration time curves for selected regimens of tafenoquine. Plasma-concentration time curves for tafenoquine generated from pharmacokinetic simulations at doses of 200 mg (a) and 100 mg (b) administered once per day for 3 days (load) then once per week for a simulated deployment of 6 months. Median trough concentrations exceed the putative MIC of 80 ng/ml for both regimens, but trough levels for the 200 mg dose exceed the MIC in 95% of subjects. The simulations utilized pharmacokinetic parameters from a US Army study [16] which were derived from modeling of data from eleven published and unpublished pharmacokinetic studies

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Malaria Journal

ISSN: 1475-2875

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