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Table 4 Summary of drug resistance allele frequencies

From: Surveillance for sulfadoxine-pyrimethamine resistant malaria parasites in the Lake and Southern Zones, Tanzania, using pooling and next-generation sequencing

Region

District

Health centre

Samples (N)

Mutant, % (number of mutant/total sequences)

dhps540

dhps581

dhfr164

Lake Zone

 Kagera

Karagwe

Kayanga

120

89% (154,320/173,457)

24.9% (46,056/185,117)

0.6% (3972/623,835)

 Kagera

Muleba

Kaigara

120

91.2% (270,373/296,323)

1% (31,77/313,669)

0% (123/286,155)

 Mara

Musoma

Murangi

117

86% (160,431/186,561)

0% (24/196,781)

0% (20/327,806)

 Mara

Tarime

Sirari

120

98.4% (262,461/266,632)

0% (71/285,418)

0% (17/249,213)

 Geita

Geita

Katoro

122

97.2% (254,986/262,202)

0.2% (547/280,267)

0% 19/310,706)

 Geita

Nyang’hwale

Kharumwa

120

92.9% (176,055/189,500)

2.4% (4860/201,156)

0% (23/322,015)

 Mwanza

Misungwi

Misasi

130

92.7% (168,879/182,105)

2% (3773/193,348)

0% (15/348,488)

 Mwanza

Sengerema

Mwangika

121

93.2% (177,559/190,591)

0.3% (692/202,087)

0% (24/386,750)

Mean allele frequency Lake Zone*

970

82.6%

3.9%

0.1%

Southern Zone

 Lindi

Lindi Rural

Kitomanga

124

94.4% (162,087/171,760)

0% (47/177,058)

0% (11/225,710)

 Lindi

Nachingwea

Marambo

129

77.3% (35,351/45,753)

0.1% (57/50,926)

0% (41/231,375)

 Mtwara

Masasi

Nagaga

160

68.1% (107,370/157,670)

0% (17/164,456)

0% (46/247,292)

 Mtwara

Mtwara

Nanguruwe

129

73.2% (104,952/143,305)

0.8% (1180/154,626)

0% (17/385,082)

 Ruvuma

Songea

Madaba

120

92% (71,494/77,751)

0% (11/83,706)

0% (13/324,890)

 Ruvuma

Namtumbo

Namtumbo

118

55.7% (26,134/46,901)

0% (12/52,484)

0% (22/318,552)

Mean allele frequency Southern Zone*

780

76.8%

0.2%

0%

  1. * Mean allele frequency for each zone was calculated by averaging the percentage of mutants from each health center