G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon

Malaria Journal

Table 2 Previous clinical complications and malaria episodes

	G6PD normal (N = 493)	G6PD deficient (N = 23)	Total (N = 516)	Crude OR [95% CI]	p value	Adjusted OR [95% CI]^a	p value
Ethnicity					0.877	–	–
European-descendant	70	3	73	−
Non-European	423	20	443	0.91 [0.26–3.13]
Previous episodes of malaria (episodes)					0.363	–	–
<3	258	11	269	1.50 [0.62–3.62]
≥3	156	10	166	–
Previous clinical complications
Anemia	68	10	78	4.81 [2.03–11.40]	<0.001	3.24 [1.26–8.27]	0.014
Jaundice	76	13	89	7.13 [3.02–16.85]	<0.001	4.02 [1.53–10.55]	0.005
Black urine	119	13	132	4.09 [1.75–9.56]	0.001	1.77 [0.68–4.62]	0.241
Need of hospitalization	324	21	345	5.48 [1.27–23.64]	0.023	3.77 [0.83–17.16]	0.086
Need of blood transfusion	38	5	43	3.33 [1.17–9.45]	0.024	1.24 [0.38–4.03]	0.723

OR odds ratio
^aLogistic regression model using clinical complications, need of hospitalization and blood transfusion

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