Ex vivo susceptibility and genotyping of Plasmodium falciparum isolates from Pikine, Senegal

Malaria Journal

Table 3 Correlation between mutation at Pfcrt codon K76T and Pfmdr1 codon N86Y and sensitivity to chloroquine, amodiaquine, piperaquine, dihydroartemisinin, and pyrimethamine

Compound	Codon	GM of IC50 (nM) for WA	GM of IC50 (nM) for MA	P value
Chloroquine	K76T	13.86	74.15	0.0195
Chloroquine	N86Y	33.90	391.2	0.0279
Amodiaquine	K76T	9.924	10.47	0.0539
Amodiaquine	N86Y	9.417	20.69	0.5290
Piperaquine	K76T	56.16	46.45	0.9370
Piperaquine	N86Y	27.15	58.00	0.8155
Dihydroartemisinin	K76T	2.139	1.773	0.4614
Dihydroartemisinin	N86Y	2.165	1.906	0.7727
Pyrimethamine	K76T	11,596	4981	0.8366
Pyrimethamine	N86Y	2.165	3.377	0.4605

P value is significant when less than 0.05
GM: geometric mean, IC ₅₀: half maximal inhibitory concentration, WA: wild allele, MA: mutant allele

ISSN: 1475-2875