Fig. 4
From: Suppression of experimental cerebral malaria by disruption of malate:quinone oxidoreductase
Parasite viability is restored by addition of fumarate or malate. Fold change of luciferase activity in control, Δfh and Δmqo parasites after cultivation. Infected erythrocytes (1 × 107) were cultured for 3 h in RPMI 1640 medium supplemented with 5 mM fumarate (Fum), 5 mM malate (Mal) or control PBS (Ctrl). Results are expressed as mean ± SD fold changes of three wells in relative luciferase units (RLU) compared with the control at 5 min after addition of d-luciferin. Experiments were performed in duplicate, and representative data are shown. Asterisks indicate statistically significant differences (*, vs. control)