Table 1 Gene and protein polymorphism of Plasmodium vivax MDR1 from different sites in Mesoamerica
Gene fragment (codons) | 444–580 nt 1330–1740 | 923–1105 nt 2767–3315 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
(Codon number) codon/one letter amino acid code | ||||||||||
Codon number | (500) | (529) | (927) | (958) | (976) | (1021) | (1070) | (1076) | ||
Sal I sequencea | gat/D | aca/T | gca/A | acg/T | tac/Y | ttc/F | ttc/F | ttt/F | ||
a../N | ..g/T | a../T | .t./M | .t./F | ..t/F | c../L | c../L | |||
n | n | |||||||||
Frequency (%) of the nucleotide changes | ||||||||||
Southern Mexico, 2008–11 | 74 | 0 | 97.3 | 64 | 0 | 96.8 | 0 | 4.6b | 3.2b | 0 |
Nicaragua | ||||||||||
NE, 2011–12 | 66 | 0 | 59.1 | 65 | 24.6 | 95.4 | 63.1 | 93.8 | 3.1c | 86.1 |
NW, 2012 | 16 | 100 | 0 | 18 | 0 | 100 | 100 | 100 | 0 | 100 |
NW, 2006–7 | 7 | 28.5 | 57.1 | 8 | 0 | 87.5 | 62.5 | 37.5 | 0 | 62.5 |
Total samples | 163 | 155 | ||||||||