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Table 2 Genetic parameters of P. vivax mdr1 gene in Mesoamerica and other geographic sites

From: Genetic diversity and natural selection of Plasmodium vivax multi-drug resistant gene (pvmdr1) in Mesoamerica

Genetic parameters

Mesoamerica

South America

Outside America

Total

SMX

NIC-NE

NIC-NW

HON

MA

BRZ

ECU

IR_PK

IND

SLK

NEP

AFR

MD

N

602

64

65

26

37

192

38

17

28

75

119

39

15

80

SS and M

18

3

6

4

2

6

8

1

3

3

2

5

4

1

H

19

4

7

4

4

10

7

2

4

4

3

5

4

2

Hd

0.769

0.150

0.553

0.348

0.377

0.666

0.414

0.441

0.206

0.462

0.533

0.398

0.638

0.025

π

0.0027

0.0004

0.0028

0.0017

0.0011

0.0036

0.0016

0.0009

0.0006

0.0012

0.0012

0.0010

0.0018

0.00005

θ

0.0054

0.0013

0.0026

0.0022

0.001

0.0022

0.0039

0.0006

0.0016

0.0009

0.0008

0.0024

0.0025

0.0004

Rm

2

0

1

0

1

2

1

0

0

0

0

0

0

0

Tests of neutrality

     

 Tajima’s D

−1.161

−1.297

0.181

−0.5699

0.3077

1.361

−1.681

0.949

−1.527

0.7437

0.853

−1.513

−0.922

−1.0526

 dNdS: Z value/P

0.116/0.908

−0.598/0.551

1.108/0.270

−0.534/0.595

1.44/0.153

−0.295/0.769

−0.570/0.57

1.046/0.298

1.667/0.098

1.337/0.184

1.371/0.173

1.845/0.067

0.416/0.678

1.047/0.297

  1. The fragment comprising 477 bp was analyzed (nucleotide fragment 2773–3249); Z test of selection (HA: dN=/=dS)
  2. SMX southern Mexico, NIC-NE Northeast Nicaragua, NIC-NW Northwest Nicaragua, HON Honduras, BRZ Brazil, ECU Ecuador, IR_PK Iran and Pakistan, IND India, SLK Sri Lanka, NEP Nepal, AFR Africa (includes samples from Sudan (n = 4), Cameroon (n = 8) and São Tomé (n = 3), MD Madagascar, N number of sequences, SS number of segregating sites, M nucleotide substitutions, H number of haplotypes, Hd haplotype diversity, π/θ indexes of diversity, Rm minimal number of recombination events