Fig. 6
Antibody responses induced by the prime-boost vaccines in protection study 1. a ELISA. PyCSP-specific antibody responses (14 mice/group) were assessed on study day 38 (SD38) and study day 52 (SD52), 5 days before and nine days after the adenovirus boost. Plates were coated with a peptide encoding a portion of the immunodominant PyCSP repeat region (QGPGAP)4. The data are presented as a box-and-whisker plot. The line within the box represents the median, the bottom and top lines of the box represent the 25th and 75th percentiles, the whiskers represent the 10th and 90th percentiles and the dots represent outliers. The lowest dilution assayed was 1/50. b IFA. PyCSP-specific antibody responses (14 mice/group) were assessed on day 52, 9 days after the adenovirus boost. The data are presented as a box-and-whisker plot. The median and upper box lines overlap in the DNA-HuAd5 data and the median and lower box lines overlap in the DNA-GC44 data. The lowest dilution assayed was 1/40