New gorilla adenovirus vaccine vectors induce potent immune responses and protection in a mouse malaria model

Malaria Journal

Table 1 Efficacy results

Vaccine	Protection^a Protected mice/total mice (% protected)				Statistical analyses
	Protection^a Protected mice/total mice (% protected)				p value
	Study 1	Study 2	Study 3	Total	Total vs. Null	Total vs. DNA-HuAd5
DNA-HuAd5	5/14 (36%)	2/14 (14%)	3/14 (21%)	10/42 (24%)	0.0011^b	–
DNA-GC44	6/14 (43%)	–	–	6/14 (43%)	0.0159^c	1.000^c
DNA-GC45	2/14 (14%)	–	–	2/14 (14%)	0.4815^c	0.3845^c
DNA-GC46	7/14 (50%)	5/14 (36%)	13/14 (93%)	25/42 (60%)	<0.0001^b	0.0018^b
Null	0/14 (0%)	0/14 (0%)	0/14 (0%)	0/42 (0%)	–
Naïve	0/14 (0%)	0/14 (0%)	0/14 (0%)	0/42 (0%)

^aThe number and percentage of mice protected in each study, as well as the total number and percentage of mice protected in all three studies is presented. Statistical analyses (two-tailed Fisher’s Exact Test) utilized data from all three studies (n = 42)^b or data from protection study 1 (n = 14)^c

ISSN: 1475-2875