Table 2 Genotype and variant allele frequency distribution among pregnant women with uncomplicated Plasmodium falciparum infection in Tanzania
Genotype | Frequency |
|---|---|
N (%) | |
CYP2B6 c.516G>T (*6) | |
*1/*1 | 38 (46.3%) |
*1/*6 | 33 (40.2%) |
*6/*6 | 11 (13.4%) |
CYP2B6 c.983T>C (*18) | |
*1/*1 | 75 (82.4%) |
*1/*18 | 15 (16.5%) |
*18/*18 | 1 (1.1%) |
CYP3A4*1B (−392A>G) | |
*1/*1 | 3 (3.2%) |
*1/*1B | 38 (41.3%) |
*1B/*1B | 51 (55.4%) |
CYP3A5*3 c.6986A>G | |
*1/*1 | 51 (56.6%) |
*1/*3 | 37 (41.1%) |
*3/*3 | 2 (2.2%) |
CYP3A5*6 c.14690G>A | |
*1/*1 | 59 (64.1%) |
*1/*6 | 28 (30.4%) |
*6/*6 | 5 (5.4%) |
CYP3A5*7 27131_27132insT | |
*1/*1 | 68 (75.6%) |
*1/*7 | 22 (24.4%) |
*7/*7 | 0 |
ABCB1 c.4036AG (rs3842) | |
AA | 54 (58.7%) |
AG | 26 (28.3%) |
GG | 12 (13.4%) |
Allele | Minor allele | % |
|---|---|---|
CYP2B6 c.516G>T (*6) | *6 | 33.5 |
CYP2B6 c.983T>C (*18) | *18 | 9.3 |
CYP3A4*1B | *1B | 76.1 |
CYP3A5*3 | *3 | 22.8 |
CYP3A5*6 | *6 | 20.6 |
CYP3A5*7 | *7 | 12.2 |
ABCB1 c.4036AG (rs3842) | G | 27.2 |