Table 6 Accuracy of RDT compared to expert microscopy for the detection of malaria in febrile children after exclusion of children with other bacterial or viral infections and previous antimalarial intake stratified per season
Accuracy parameters | Whole year | Dry season | Rainy season | |||
|---|---|---|---|---|---|---|
Value % (n/N) | 95% CI | Value % (n/N) | 95% CI | Value % (n/N) | 95% CI | |
Accuracy after exclusion of bBSI, UTI, vGII and previous antimalarial intake | ||||||
Sensitivity | 98.2 (320/326) | 96.0–99.3 | 96.7 (89/92) | 90.8–99.3 | 98.7 (231/234) | 96.3–99.7 |
Specificity | 63.0 (162/257) | 56.8–69.0 | 67.6 (127/188) | 60.4–74.2 | 50.7 (35/69) | 38.4–63 |
PPV | 77.1 (320/415) | 72.8–81.1 | 59.3 (89/150) | 51–67.3 | 87.2 (231/265) | 82.5–90.9 |
NPV | 96.4 (162/168) | 92.4–98.7 | 97.7 (127/130) | 93.4–99.5 | 92.1 (35/38) | 78.6–98.3 |
Accuracy after exclusion of bBSI | ||||||
Sensitivity | 98.2 (328/334) | 96.1–99.3 | 96.8 (91/94) | 91–99.3 | 98.8 (237/240) | 96.4–99.7 |
Specificity | 61.7 (190/308) | 56–67.1 | 65.9 (153/232) | 59.5–72 | 48.7 (37/76) | 37–60.4 |
PPV | 73.5 (328/446) | 69.2–77.6 | 53.5 (91/170) | 45.7–61.2 | 85.9 (237/276) | 81.2–89.8 |
NPV | 96.9 (190/196) | 93.5–98.9 | 98.1 (153/156) | 94.5–99.6 | 92.5 (37/40) | 79.6–98.4 |
Accuracy after exclusion of UTI | ||||||
Sensitivity | 98.2 (329/335) | 96.1–99.3 | 97.0 (97/100) | 91.5–99.4 | 98.7 (232/235) | 96.3–99.7 |
Specificity | 59.8 (201/336) | 54.4–65.1 | 65.7 (159/242) | 59.4–71.7 | 44.7 (42/94) | 34.4–55.3 |
PPV | 70.9 (329/464) | 66.5–75 | 53.9 (97/180) | 46.3–61.3 | 81.7 (232/284) | 76.7–86 |
NPV | 97.1 (201/207) | 93.8–98.9 | 98.1 (159/162) | 94.7–99.6 | 93.3 (42/45) | 81.7–98.6 |
Accuracy after exclusion of vGII | ||||||
Sensitivity | 98.2 (326/332) | 96.2–99.3 | 96.9 (94/97) | 91.2–99.4 | 98.7 (232/235) | 96.4–99.7 |
Specificity | 59.7 (188/315) | 53.3–64.3 | 66.5 (147/221) | 59.8–72.5 | 43.6 (41/94) | 31.9–52.2 |
PPV | 72.0 (326/453) | 67.1–75.6 | 55.9 (94/168) | 47.8–63.2 | 81.4 (232/285) | 75.6–85 |
NPV | 96.9 (188/194) | 93.4–98.9 | 98.0 (147/150) | 94.3–99.6 | 93.2 (41/44) | 81.3–98.6 |
Accuracy after exclusion of UTI and vGII | ||||||
Sensitivity | 98.2 (325/331) | 96.1–99.3 | 96.9 (94/97) | 91.2–99.4 | 98.7 (231/234) | 96.3–99.7 |
Specificity | 60.2 (171/284) | 54.3–65.9 | 67.2 (133/198) | 60.2–73.7 | 44.2 (38/86) | 33.5–55.3 |
PPV | 74.2 (325/438) | 69.8–78.2 | 59.1 (94/159) | 51.1–66.8 | 82.8 (231/279) | 77.8–87 |
NPV | 96.6 (171/177) | 92.8–98.7 | 97.8 (133/136) | 93.7–99.5 | 92.7 (38/41) | 80.1–98.5 |
Accuracy after exclusion of antimalarial intake during the previous 2 weeks | ||||||
Sensitivity | 98.2 (333/339) | 96.2–99.3 | 97.0 (97/100) | 91.5–99.4 | 98.7 (236/239) | 96.4–99.7 |
Specificity | 58.9 (182/309) | 53.2–64.4 | 65.6 (143/218) | 58.9–71.9 | 42.9 (39/91) | 32.5–53.7 |
PPV | 72.4 (333/460) | 68.1–76.4 | 56.4 (97/172) | 48.6–63.9 | 81.9 (236/288) | 77–86.2 |
NPV | 96.8 (182/188) | 93.2–98.8 | 97.9 (143/146) | 94.1–99.6 | 92.9 (39/42) | 80.5–98.5 |