TY - JOUR AU - Thanh, N. V. AU - Thuy-Nhien, N. AU - Tuyen, N. T. AU - Tong, N. T. AU - Nha-Ca, N. T. AU - Dong, L. T. PY - 2017 DA - 2017// TI - Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin-piperaquine in the south of Vietnam JO - Malar J VL - 16 UR - https://doi.org/10.1186/s12936-017-1680-8 DO - 10.1186/s12936-017-1680-8 ID - Thanh2017 ER - TY - JOUR AU - Imwong, M. AU - Suwannasin, K. AU - Kunasol, C. AU - Sutawong, K. AU - Mayxay, M. AU - Rekol, H. PY - 2017 DA - 2017// TI - The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong Subregion: a molecular epidemiology observational study JO - Lancet Infect Dis VL - 17 UR - https://doi.org/10.1016/S1473-3099(17)30048-8 DO - 10.1016/S1473-3099(17)30048-8 ID - Imwong2017 ER - TY - JOUR AU - Trape, J. F. PY - 2001 DA - 2001// TI - The public health impact of chloroquine resistance in Africa JO - Am J Trop Med Hyg VL - 64 UR - https://doi.org/10.4269/ajtmh.2001.64.12 DO - 10.4269/ajtmh.2001.64.12 ID - Trape2001 ER - TY - JOUR AU - Nosten, F. AU - Kuile, F. O. AU - Luxemburger, C. AU - Woodrow, C. AU - Kyle, D. E. AU - Chongsuphajaisiddhi, T. PY - 1993 DA - 1993// TI - Cardiac effects of antimalarial treatment with halofantrine JO - Lancet VL - 341 UR - https://doi.org/10.1016/0140-6736(93)92412-M DO - 10.1016/0140-6736(93)92412-M ID - Nosten1993 ER - TY - JOUR AU - Duparc, S. AU - Borghini-Fuhrer, I. AU - Craft, C. J. AU - Arbe-Barnes, S. AU - Miller, R. M. AU - Shin, C. S. PY - 2013 DA - 2013// TI - Safety and efficacy of pyronaridine-artesunate in uncomplicated acute malaria: an integrated analysis of individual patient data from six randomized clinical trials JO - Malar J VL - 12 UR - https://doi.org/10.1186/1475-2875-12-70 DO - 10.1186/1475-2875-12-70 ID - Duparc2013 ER - TY - JOUR AU - Sagara, I. AU - Beavogui, A. H. AU - Zongo, I. AU - Soulama, I. AU - Borghini-Fuhrer, I. AU - Fofana, B. PY - 2016 DA - 2016// TI - Safety and efficacy of re-treatments with pyronaridine-artesunate in African patients with malaria: a substudy of the WANECAM randomised trial JO - Lancet Infect Dis VL - 16 UR - https://doi.org/10.1016/S1473-3099(15)00318-7 DO - 10.1016/S1473-3099(15)00318-7 ID - Sagara2016 ER - TY - JOUR AU - Leang, R. AU - Canavati, S. E. AU - Khim, N. AU - Vestergaard, L. S. AU - Fuhrer, I. B. AU - Kim, S. PY - 2016 DA - 2016// TI - Efficacy and safety of pyronaridine-artesunate for treatment of uncomplicated Plasmodium falciparum malaria in western Cambodia JO - Antimicrob Agents Chemother VL - 60 UR - https://doi.org/10.1128/AAC.00039-16 DO - 10.1128/AAC.00039-16 ID - Leang2016 ER - TY - JOUR AU - Looareesuwan, S. AU - Viravan, C. AU - Webster, H. K. AU - Kyle, D. E. AU - Hutchinson, D. B. AU - Canfield, C. J. PY - 1996 DA - 1996// TI - Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand JO - Am J Trop Med Hyg VL - 54 UR - https://doi.org/10.4269/ajtmh.1996.54.62 DO - 10.4269/ajtmh.1996.54.62 ID - Looareesuwan1996 ER - TY - JOUR AU - White, N. J. PY - 2016 DA - 2016// TI - Can new treatment developments combat resistance in malaria? JO - Expert Opin Pharmacother VL - 17 UR - https://doi.org/10.1080/14656566.2016.1187134 DO - 10.1080/14656566.2016.1187134 ID - White2016 ER - TY - JOUR AU - White, N. J. AU - Pukrittayakamee, S. AU - Phyo, A. P. AU - Rueangweerayut, R. AU - Nosten, F. AU - Jittamala, P. PY - 2014 DA - 2014// TI - Spiroindolone KAE609 for falciparum and vivax malaria JO - N Engl J Med VL - 371 UR - https://doi.org/10.1056/NEJMoa1315860 DO - 10.1056/NEJMoa1315860 ID - White2014 ER - TY - JOUR AU - Rottmann, M. AU - McNamara, C. AU - Yeung, B. K. S. AU - Lee, M. C. S. AU - Zou, B. AU - Russell, B. PY - 2010 DA - 2010// TI - Spiroindolones, a potent compound class for the treatment of malaria JO - Science VL - 329 UR - https://doi.org/10.1126/science.1193225 DO - 10.1126/science.1193225 ID - Rottmann2010 ER - TY - JOUR AU - White, N. AU - Thanh, D. T. AU - Uthaisil, C. AU - Nosten, F. AU - Phyo, A. P. AU - Hanboonkunupakarn, B. PY - 2016 DA - 2016// TI - Antimalarial activity of KAF156 in falciparum and vivax malaria JO - N Engl J Med VL - 375 UR - https://doi.org/10.1056/NEJMoa1602250 DO - 10.1056/NEJMoa1602250 ID - White2016 ER - TY - STD TI - Tran HT, White NJ, Nguyen T-NT, Nhu HT, Phung TD, Tarning J, et al. Estimation of the in vivo minimum inhibitory concentration of cipargamin in uncomplicated Plasmodium falciparum malaria. Antimicrob Agents Chemother. 2016:AAC. Abstract 01940-16. ID - ref13 ER - TY - JOUR AU - Kuhen, K. L. AU - Chatterjee, A. K. AU - Rottmann, M. AU - Gagaring, K. AU - Borboa, R. AU - Buenviaje, J. PY - 2014 DA - 2014// TI - KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission JO - Antimicrob Agents Chemother VL - 58 UR - https://doi.org/10.1128/AAC.02727-13 DO - 10.1128/AAC.02727-13 ID - Kuhen2014 ER - TY - JOUR AU - Leong, F. J. AU - Zhao, R. AU - Zeng, S. AU - Magnusson, B. AU - Diagana, T. T. AU - Pertel, P. PY - 2014 DA - 2014// TI - A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel Imidazolopiperazine KAF156 to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers JO - Antimicrob Agents Chemother VL - 58 UR - https://doi.org/10.1128/AAC.03478-14 DO - 10.1128/AAC.03478-14 ID - Leong2014 ER - TY - JOUR AU - Magistrado, P. A. AU - Corey, V. C. AU - Lukens, A. K. AU - LaMonte, G. AU - Sasaki, E. AU - Meister, S. PY - 2016 DA - 2016// TI - Plasmodium falciparum cyclic amine resistance locus (PfCARL), a resistance mechanism for two distinct compound classes JO - ACS Infect Dis VL - 2 UR - https://doi.org/10.1021/acsinfecdis.6b00025 DO - 10.1021/acsinfecdis.6b00025 ID - Magistrado2016 ER - TY - JOUR AU - McCarthy, J. S. AU - Baker, M. AU - O’Rourke, P. AU - Marquart, L. AU - Griffin, P. AU - Hooft van Huijsduijnen, R. PY - 2016 DA - 2016// TI - Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers JO - J Antimicrob Chemother VL - 71 UR - https://doi.org/10.1093/jac/dkw174 DO - 10.1093/jac/dkw174 ID - McCarthy2016 ER - TY - JOUR AU - Phyo, A. P. AU - Jittamala, P. AU - Nosten, F. H. AU - Pukrittayakamee, S. AU - Imwong, M. AU - White, N. J. PY - 2016 DA - 2016// TI - Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial JO - Lancet Infect Dis VL - 16 UR - https://doi.org/10.1016/S1473-3099(15)00320-5 DO - 10.1016/S1473-3099(15)00320-5 ID - Phyo2016 ER - TY - JOUR AU - Darpo, B. AU - Ferber, G. AU - Siegl, P. AU - Laurijssens, B. AU - Macintyre, F. AU - Toovey, S. PY - 2015 DA - 2015// TI - Evaluation of the QT effect of a combination of piperaquine and a novel anti-malarial drug candidate OZ439, for the treatment of uncomplicated malaria JO - Br J Clin Pharmacol VL - 80 UR - https://doi.org/10.1111/bcp.12680 DO - 10.1111/bcp.12680 ID - Darpo2015 ER - TY - JOUR AU - Uhlemann, A. C. AU - Wittlin, S. AU - Matile, H. AU - Bustamante, L. Y. AU - Krishna, S. PY - 2007 DA - 2007// TI - Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277) JO - Antimicrob Agents Chemother VL - 51 UR - https://doi.org/10.1128/AAC.01064-06 DO - 10.1128/AAC.01064-06 ID - Uhlemann2007 ER - TY - JOUR AU - Patil, C. AU - Katare, S. AU - Baig, M. AU - Doifode, S. PY - 2014 DA - 2014// TI - Fixed dose combination of arterolane and piperaquine: a newer prospect in antimalarial therapy JO - Ann Med Health Sci Res. VL - 4 UR - https://doi.org/10.4103/2141-9248.139270 DO - 10.4103/2141-9248.139270 ID - Patil2014 ER - TY - JOUR AU - Saha, N. AU - Moehrle, J. J. AU - Zutshi, A. AU - Sharma, P. AU - Kaur, P. AU - Iyer, S. S. PY - 2014 DA - 2014// TI - Safety, tolerability and pharmacokinetic profile of single and multiple oral doses of arterolane (RBx11160) maleate in healthy subjects JO - J Clin Pharmacol VL - 54 UR - https://doi.org/10.1002/jcph.232 DO - 10.1002/jcph.232 ID - Saha2014 ER - TY - JOUR AU - Valecha, N. AU - Krudsood, S. AU - Tangpukdee, N. AU - Mohanty, S. AU - Sharma, S. K. AU - Tyagi, P. K. PY - 2012 DA - 2012// TI - Arterolane maleate plus piperaquine phosphate for treatment of uncomplicated Plasmodium falciparum malaria: a comparative, multicenter, randomized clinical trial JO - Clin Infect Dis VL - 55 UR - https://doi.org/10.1093/cid/cis475 DO - 10.1093/cid/cis475 ID - Valecha2012 ER - TY - JOUR AU - Dondorp, A. M. AU - Nosten, F. AU - Yi, P. AU - Das, D. AU - Phyo, A. P. AU - Tarning, J. PY - 2009 DA - 2009// TI - Artemisinin resistance in Plasmodium falciparum malaria JO - N Engl J Med VL - 361 UR - https://doi.org/10.1056/NEJMoa0808859 DO - 10.1056/NEJMoa0808859 ID - Dondorp2009 ER - TY - JOUR AU - Ashley, E. A. AU - Dhorda, M. AU - Fairhurst, R. M. AU - Amaratunga, C. AU - Lim, P. AU - Suon, S. PY - 2014 DA - 2014// TI - Spread of artemisinin resistance in Plasmodium falciparum malaria JO - N Engl J Med VL - 371 UR - https://doi.org/10.1056/NEJMoa1314981 DO - 10.1056/NEJMoa1314981 ID - Ashley2014 ER - TY - JOUR AU - Taylor, A. R. AU - Flegg, J. A. AU - Holmes, C. C. AU - Guerin, P. J. AU - Sibley, C. H. AU - Conrad, M. D. PY - 2017 DA - 2017// TI - Artemether-lumefantrine and dihydroartemisinin-piperaquine exert inverse selective pressure on Plasmodium falciparum drug sensitivity-associated haplotypes in Uganda JO - Open Forum Infect Dis VL - 4 ID - Taylor2017 ER - TY - STD TI - ClinicalTrials.gov. A study by the tracking resistance to artemisinin collaboration (TRAC) (TRACII). ClinicalTrialsgov Identifier: NCT02453308 2015. ID - ref27 ER -