TY - JOUR AU - Holmberg, Dag AU - Franzén-Röhl, Elisabeth AU - Idro, Richard AU - Opoka, Robert O. AU - Bangirana, Paul AU - Sellgren, Carl M. AU - Wickström, Ronny AU - Färnert, Anna AU - Schwieler, Lilly AU - Engberg, Göran AU - John, Chandy C. PY - 2017 DA - 2017/07/28 TI - Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria JO - Malaria Journal SP - 303 VL - 16 IS - 1 AB - One-fourth of children with cerebral malaria (CM) retain cognitive sequelae up to 2 years after acute disease. The kynurenine pathway of the brain, forming neuroactive metabolites, e.g. the NMDA-receptor antagonist kynurenic acid (KYNA), has been implicated in long-term cognitive dysfunction in other CNS infections. In the present study, the association between the kynurenine pathway and neurologic/cognitive complications in children with CM was investigated. SN - 1475-2875 UR - https://doi.org/10.1186/s12936-017-1954-1 DO - 10.1186/s12936-017-1954-1 ID - Holmberg2017 ER -